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Health & safety
Don't swim in the river itself, as there is a chance of picking up parasites. Bring repellent and sun-screen with you. Make sure hotel has mosquito net. Also, as you will travel by boat and ferry quite often in Mekong Delta, be careful when embarking or disembarking. Check out best time to visit Mekong Delta and stay tuned to weather forecast for flood news in the area if any. Then just enjoy your trip!
If time allowed, Cai Rang floating market is really worth visiting on your way to explore the Mekong Delta. Almost floating markets start in the very early morning and finish before noon. Thus, to catch the liveliest and busiest scenery, you should plan to stay one night in Can Tho.
Wherever you go in the delta (except for My Tho), be prepared for ferry crossings which may take you few hours.